Before another transfer after repeated failures, the highest-value move is a structured review of what has already been checked — not more random testing. The checklist below organizes the evidence-based work-up into uterine, embryo, and systemic buckets so nothing obvious is missed and nothing unproven is over-ordered. A normal cavity plus normal embryos with no…
After repeated failed transfers, the consult should produce a plan, not just sympathy. These ten questions steer the conversation from “it didn’t work” to a structured review you can act on. Bring your transfer log and PGT-A results, and write the answers down. The aim is to find the next useful, evidence-based step — not…
When transfers keep failing, your records — lining thickness, beta-hCG, PGT-A results, and uterine imaging — are the map. This guide decodes the usual numbers so you can see whether the issue is the cavity, the embryo, or timing, and walk into the consult with specifics instead of a vague “it didn’t work.” General education,…
A large share of RIF stays “unexplained” after a full, guideline-based work-up — and that is a finding, not a failure of your doctor. The real risk is over-testing: immune panels, “natural killer” cell assays, and exotic treatments are widely marketed but are not endorsed by ASRM or ESHRE for routine RIF. This article separates…
RIF is often framed as a “woman’s problem,” but the sperm contribution is real and frequently untested. Beyond the standard sperm count and motility, DNA fragmentation (DFI) reflects broken genetic material that a standard analysis misses; higher DFI is associated with lower implantation and higher early pregnancy loss — especially when embryos look good. Testing…
After repeated failed transfers, changing the protocol is tempting — but, as with day-3 arrest, it should be a decision tied to a finding, not a reflex. The right move depends on which domain your work-up implicates: a cavity problem needs surgery, not a new drug; an unexplained case needs caution against unproven “boosters.” This…
Recurrent implantation failure (RIF) means a competent embryo repeatedly fails to attach and establish a pregnancy. A common working definition is the failure to achieve a clinical pregnancy after transferring good-quality embryos across at least three IVF/ICSI cycles — often cited as 10 or more good embryos — in a woman under 40 (Coughlan et…
A failed euploid embryo transfer means a chromosomally normal (PGT-A–tested) embryo was placed in the uterus but did not result in a pregnancy. It is a specific, common scenario: after two or three such failures, the problem shifts away from embryo chromosomes toward the endometrium and other receptivity factors. Importantly, “euploid” sharply lowers — but…